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TRIM59 promotes hepatic steatosis and ferroptosis by enhancing GPX4 ubiquitination, leading to its degradation and subsequent loss of antioxidant activity ( 4 Potential effective therapies targeting ferroptosis for NAFLD 4.1 Ferroptosis inhibitors Fer-1 is a selective and potent inhibitor of ferroptosis, known for its ability to scavenge lipid radicals and prevent lipid peroxidation