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Description

The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups

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SPAE treatment attenuated Keap1 expression, implying the release and nuclear translocation of Nrf2 , thereby enhancing endogenous antioxidant defences

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Res Commun Chem Pathol Pharmacol, 35: 283-290

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