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If mishandled, it should be handled only in qualified research facilities with institutional biosafety oversight

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While the aglycone quercetin exhibits potent in vitro anti-inflammatory and antioxidant activitiesprimarily driven by the 2,3-double bond of the C-ring and the catechol B-ring (3',4'-dihydroxy groups)its clinical translation is frequently hindered by rapid first-pass metabolism and poor pharmacokinetic stability ( in vivo efficacy and toxicity profiles

This metabolic pathway generates nicotinamide adenine dinucleotide phosphate (NADPH) and ribose 5-phosphate (R5P) (47)