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According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy

European Journal of Clinical Nutrition, [online] 72(1), pp.105111

This suggests that Formononetin exhibits good in vivo safety and does not pose significant toxicity to nude mice

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