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10.1016/j.tins.2018.05.005 7 BlanchetteM.DanemanR

Review of late-stage Alzheimer's drug development Successes and Failures for Drugs in Late-Stage Development for Alzheimer's Disease

104 Subsequent degradation of TJs results in the release of cytokines, including interleukin-1 (IL-1), tumor necrosis factor (TNF), and MMPs

For compounds that give negative results, the completion of either option of the standard test battery, performed and evaluated in accordance with current recommendations, will usually provide sufficient assurance of the absence of genotoxic activity and no additional tests are warranted