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In addition, they also documented several immunity and immunity linked biological signaling pathways (B cell receptor signaling pathways, TNF signaling pathway, IL-17 signaling pathway and NF-B signaling pathway) which is in consistent with findings reported previously (165, 173)

On one hand, 16-OHE activates ER, leading to upregulation of nicotinamide adenine dinucleotide phosphate oxidase (Nox)1 and Nox4 expression and increases reactive oxygen species (ROS) production, mainly superoxide anion and hydrogen peroxide, mediated by these enzymes