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Recent investigations have indicated that individuals with advanced depression exhibit a significant imbalance in OS, characterized by elevated levels of free 8-iso-prostaglandins (a lipid peroxidation product) and declined activity of glutathione peroxidase, an important antioxidant defense mechanism (141143)

The coordinated response between gene regulation and metabolic adaptation is demonstrated by the alignment of over-represented pathways, including UDP-N-acetyl-glucosamine synthesis, N-glycan biosynthesis, and lipid metabolism, all of which play a role in supporting osmoregulatory function

Glutathione is a powerful antioxidant with significant roles in cellular health, particularly in the kidneys

Additionally, we have developed a model whereby P