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Curr Opin Otolaryngol Head Neck Surg 18(2):101-106, 2010

Interestingly, the insulin sensitivity of old mice was the same as that of young mice after 7 days of MOTS-c intervention (7)

In type 2 diabetic mice, Simiao Wan (SMW) and its bioactive ingredients (including CGA and berberine) reduced fasting glucose and lipid levels, improved insulin levels, and activated the IRS1/AKT2/GLUT2 signaling pathway while inhibiting FOXO1, confirming the glucose-lowering effects of CGA through enhanced hepatic insulin signaling [152]