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These cellular populations demonstrate the heterogeneity of the graft microenvironment and highlight the active involvement of multiple cell types in tissue remodeling and regeneration

In subsequent experiments, the cells were treated as follows: solvent (PBS) as a control

Recent studies have highlighted the role of mitochondrial impairment and altered energy metabolism as key contributors to the pathophysiology of GWS, with their severity correlating to disease progression in 19 veterans suffering from GWS and 17 healthy controls, comparing these factors to markers of peripheral inflammation (Golomb et al., 2023)

In addition, we only assessed the protective activity of LSC-Exo against SARS-CoV-2 at 2 h post-inhalation and the therapeutic efficacy of LSC-Exo on day 1 after SARS-CoV-2 challenge, longer intervals should be tested in the future