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Static compression significantly inhibits the viability, migration, clonogenicity, and multidifferentiation potential of NP-MSCs and reduces their stemness, suggesting it may play an important role in hindering endogenous disc repair ( Furthermore, the physical properties of the substrate (such as stiffness and fiber alignment) also significantly regulate stem cell differentiation

doi: 10.1155/2022/2521025 92 WangJZhangQLiYPanXShanYZhangJ

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