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Activation of microglia upregulates MHC I expression on neurons, promoting neuronal presentation of -synuclein antigen

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Metallothionein-3 (MT3), a brain-specific metalloprotein, serves as a primary antioxidant that rapidly responds to oxidative stress

These concepts are schematically illustrated in Figure 2 highlighting how therapy-driven clonal selection can be longitudinally tracked using tissue and liquid biopsy approaches