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Furthermore, the cleavage of GSDMD (gasdermin D) by CASP1 and CASP11 to produce an N-terminal fragment of GSDMD (GSDMD-N) is a key event driving infection-associated pyroptotic cell death [117]

Its effects concentrate in the area of administration, making it ideal for targeting specific tendons, ligaments, or muscle injuries

Microglial expression of NLRP3, AIM2, and ZBP1 increases after SCI, and caspase-8, caspase-1, RIPK1/RIPK3 are all upregulated in parallel

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