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doi: 10.18632/oncotarget.17589 83 ChenYHMcGowanLDCiminoPJDahiyaSLeonardJRLeeDYet al

NNMT inhibition increases cellular concentrations of both substrates that the enzyme would otherwise consume: SAM (the universal methyl donor) and nicotinamide (the NAD + salvage precursor)

Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells