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Epub 2010 Dec 2

Preclinical Observations Findings observed in murine studies include: Endurance capacity: Increased treadmill running time and distance Mitochondrial function: Enhanced respiration and ATP production in muscle Cardiac metabolism: Improved fatty acid utilization in models of heart failure Renal function: Reduced mitochondrial dysfunction and inflammation in aging kidney models Metabolic profile: Improved glucose handling in metabolic syndrome models These results are limited to animal models using intraperitoneal injection

This gastric pentadecapeptide demonstrates anti-inflammatory properties, cytoprotective effects, and influences on multiple neurotransmitter systems

The successful localization of the capsid precursors to the replication complex in BSO-treated cells suggest that the structural (conformational) change in the capsid precursor due to GSH-depletion does not affect the direct protein-protein interactions between the VP3-component of capsid precursors and 2C ATPase on the replication complex