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However, oxidation of cysteine residues on KEAP1 including Cys151, Cys273, and Cys288 by H 2 O 2 induces a conformational change in KEAP1 and stimulates the activation of Nrf2 150

Brain 2018;141:1917-33

The anti-pharma industry position is understandable, with many scandals that have plagued the industry (such as Vioxx, Oxycontin, and several others) without any accountability of the companies or their senior management