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This disparity underscores a critical knowledge gap that must be resolved before confident, evidence-based clinical adoption can be justified

Ferroptosis, as the most enriched programmed cell death process in glioma, induces immunosuppression and immunotherapy resistance

Blocking mitochondrial pyruvate carriers by UK-5099 in T315I-Bcr-Abl cells reduces GSH level to induce replication stress

Supporting this interpretation, a previous clinical study reported that individuals carrying SNPs associated with reduced GLUT2 expression exhibit greater responsiveness to metformin, further suggesting that decreased intestinal glucose absorption mediated by reduced expression of glucose transporters such as GLUT2 may play an important role in enhancing overall glucose homeostasis after metformin administration 52