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Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression

This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability

J.Nutr.Health Aging 2010;14(3):224-230

Carnitine promotes the influx of Ca 2+ from the extracellular environment through the depolarization of L-type Ca 2+ channels, providing an impetus for the initial activation of intracellular calcium signaling