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Without being bound to copper, GHK has been shown to be a quencher of cytotoxic end products of lipid peroxidation such as ,-4-hydroxy-trans-2-nonenal and acrolein, which can be associated with severe pathologies such as diabetes and neurodegenerative disease [18- 19]

Solutions: Rotate injection sites more frequently Use new needle every time Clean site thoroughly with alcohol Let alcohol dry before injecting If persistent, reduce dose or switch to oral Usually harmless: Minor reactions common Should resolve within hours to days Not dangerous unless signs of infection (warmth, spreading redness, fever) No results after 4 weeks Problem: Not seeing expected healing or improvements

Continued research and collaboration across disciplines concomitantly with involving patients representation in every step of the process, are essential to overcome these barriers and fully realize the potential of gene editing in revolutionizing cardiovascular and metabolic disease management

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