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Other, more indirect strategies have evolved to translate cAMP signals into changes in POMC gene expression involving a CREB/c-Fos/AP-1 signaling cascade activating POMC transcription via an activator protein-1 (AP-1) site in exon 1

Our review also explores the therapeutic potential and research directions of epigenetic interventions from multiple perspectives, including strategies targeting epigenetic drug resistance mechanisms, the influence of resistance subtypes, and tumor heterogeneity on treatment efficacy