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5 Hypoxic stress at high altitude can trigger a series of physiological responses across multiple organ systems, especially the brain (increased cerebral blood flow), pulmonary system (increased ventilation and pulmonary vascular remodeling), cardiovascular system (increased heart rate, cardiac output, and systemic blood pressure), renal system (increased bicarbonate excretion and erythropoietin (EPO) secretion), and hematologic system (increased red cell mass, hemoglobin (Hb) concentration, and hematocrit (Hct)), thereby increasing oxygen content and delivery in the body

Over time, various methods for generating ABTS + have been introduced, differing in reaction strategies, applied reaction times, detection wavelengths, and reference antioxidants

Because passive wrapping is ineffective for some amphiphilic drugs, active loading methods have been developed to reduce leakage while improving efficiency [33]

For determination of the GSH:GSSG ratio, HPLC-ED was optimised and used