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doi: 10.3389/fimmu.2022.762580 121 ZelanteTIannittiRGCunhaCDe LucaAGiovanniniGPieracciniGet al

The 3' untranslated region of the PDCD4 gene is directly targeted by miR-21, and PDCD4 expression is inhibited in a dose-dependent manner by miR-21 [117]

These outcomes highlight challenges such as inter-individual differences (what works in one persons gut may not in anothers), timing (intervening too late in disease may limit benefits), and the need for biomarkers to identify who is most likely to respond

In a murine tumor model, it was found that nearly all TIL-Treg expressing specific T cell receptors were directed against tumor-associated antigens