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(A gray market of non-reputable pharmacies may dispense KPV for use with for research purposes labeling, but these are often nonaccredited and unregulated sources.) What the science says: What we currently know about KPV comes almost entirely from lab and animal studies

This is especially important for people at risk for multiple deficiencies, including those with GI conditions, a history of gastric bypass surgery, impaired kidney function, older adults, and people taking PPIs

In fact, the expression of those genes was lowered to levels similar to those of acne patients." So it looks like by intaking extra vitamin B12, we could be prompting the bacteria in our skin to slow down on their production of it, which leads to an imbalance that could heighten our risk of developing acne

Biochim Biophys Acta Mol Cell Res