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Yuan JX-J, Aldinger AM, Juhaszova M, Wang J, Conte JV, Gaine SP, et al

Caspase-dependent and caspase-independent oligodendrocyte death mediated by AMPA and kainate receptors

These observations raise an intriguing possibility that insults in HSCs over the lifespan are a driver of maladaptive trained immunity, resulting in aging-associated inflammation and functional decline of distant tissues