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Through strategic communications and policy advocacy campaigns, we work to change public attitudes about tobacco and promote proven policies that are most effective at reducing tobacco use and saving the most lives

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Industry players have invested heavily in research to show that noncombustible products present much lower exposure to toxic substances than conventional cigarettes

Combined with lack of proliferation (Ki67-) or reduced expression of canonical markers for antitumoral responses such as interferon gamma (IFN) or cytolytic Perforin (PRF1) in these CD8+ T cells, this suggests impaired antitumoral T cell fitness and contribution to protumoral inflammation ( Supplementary Figure S5 )