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Role of glutathione in the regulation of Cisplatin resistance in cancer chemotherapy

the conjugates were provided in ethanol (approximately 40 mg analog/2 ml ethanol)

Therefore, future work necessitates the use of appropriate animal models, including tumor xenografts and potentially genetically engineered mouse models, to evaluate PAs ability to trigger ferroptosis in vivo (assessed via relevant biomarkers like tumor iron levels, lipid ROS, and marker protein expression) and to ascertain its safety profile regarding potential off-target effects in normal tissues

However, in sepsis they can lead to an unbalanced host response that can potentially trigger a life-threatening cytokine storm [1, 9]