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Conversely, we define Treg exhaustion more specifically as a state induced by chronic inflammation, characterized by persistent expression of inhibitory receptors (e.g., PD-1/TIGIT), metabolic insufficiency, epigenetic and lineage instability (such as FOXP3 destabilization), and a decline in suppressive capacity, particularly in the context of continuous antigenic and cytokine stimulation

c, Protein expression (western blot) of GPX4, ACLS4, and LPCAT3 in HK-2 cells treated with 20 ng/mL for 48 h in the presence or absence of Fer-1 (2 M) for 48 h ( n =3)

reported that among 100 patients with PG, 49% had a significant impact and 22% an extremely significant impact on quality of life.54 Parihar et al

Allergy Asthma Proc (2004) 25(5):297304