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It has been shown that excessive ROS may promote neuroinflammation and tissue damage by enhancing T-cell activity via the arachidonic acid cascade and by directly or indirectly impairing the integrity of BBB and myelin (Winyard and Blake, 1997)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Seiwerth S., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., Drmic D., Stupnisek M., Misic M., Vuletic L.B., et al

However, continuous exposure to sunlight without sunscreen can bring pigmentation back