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Peng Y, Pan W, Ou Y, et al

The mechanism of PRDM16 in AT is as follows: PRDM16 directly activates the thermogenic function of BAT and induces the browning of WAT by binding to the promoter of UCP1 and PPAR- coactivator 1 (PGC1), indirectly regulates AT function by promoting SLIT2 protein secretion and inducing -hydroxybutyrate (BHB) secretion [465]