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A recent cryoEM study, for the first time, characterized the structure of full-length AR and defined interaction sites between AR NTD and key AR coregulators p300 and SRC3 [48]

CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle