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Controls were mainly characterized by a high expression of SOD1 protein, whereas sALS samples were characterized by high Ci for complexes I and IV (a coefficient that represents the control of metabolic fluxes by a given enzyme), and fALS samples were characterized by a high rate of maximal respiration with substrates for complexes I and II and a high level of the complex I NDUFB8 subunit

[DOI] [PubMed] [Google Scholar] 14.Yang P., Wang Y.X., Sun L., Chen Y.J., Liu C., Huang L.L., Lu W.Q., Zeng Q

(2009), mGpx4 -/- (mitochondrial GPx4) knockout mice are infertile and have less motile and progressive sperm compared to WT

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4