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Since COPD increases susceptibility to lower respiratory tract infections, preventive vaccines , such as pneumococcal and influenza vaccinations, are recommended in all COPD cases (ICSI 2011)

It is not possible to know with certainty whether a new therapy reliably decreases pain in the absence of a placebo control group

[34] A synthesis of the Cholesterol Lowering Atherosclerosis Study and the Monitored Atherosclerosis Regression Study (MARS) concluded that lipid lowering can halt progression and produce angiographically detectable regression, while emphasizing that the absolute changes in lumen diameter are small relative to the accompanying reduction in clinical events