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Recently, Wangs team discovered that the promoter region of GPX4 binds to cyclic adenosine monophosphate response element binding protein (CREB) and that this binding can be enhanced by E1A binding protein P300 (EP300), promoting tumor proliferation, migration, invasion and angiogenesis

Different from GSH-TPGS, GSH-PEG employed GSHs thiol group ( S -terminal) for linkage to PEG to form a thioether bond instead of an ester bond derived from the C -terminal linkage of the glycine carboxylic acid in GSH-TPGS