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Subjects with more severe hepatic impairment (i.e., higher ChildPugh scores) might have increases in apixaban exposure due to more significantly reduced CYP-mediated metabolism, despite the presence of other elimination pathways

Obesity Treatment For individuals with obesity (BMI 30) or overweight (BMI 27 with weight-related comorbidities): Standard dose: 2.4 mg weekly after titration Duration: Long-term maintenance therapy Monitoring: Regular weight, metabolic parameters, side effects The REDEFINE 1 trial specifically enrolled this population, providing robust evidence for efficacy and safety

Nabeshima, K

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