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Receptors in the glutamate signaling cascade include ionotropic receptors (which act quickly, opening upon agonist binding and enable ion flow) and metabotropic receptors (which are G-protein-coupled receptors that help modulate synaptic activity and plasticity over a longer timescale) (Fig

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The dose was divided into two doses with a taper period in which just half of the target dose was given for the first 2 weeks

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