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Corticosterone effects on postnatal cerebellar development in mice

Gerin, I

In a subsequent study using NFE2L2/PGC1 double knockout (dKO) mice model, they observed upregulation of autophagy markers PINK1 and PARKIN together with damaged mitochondria, with no increase in the colocalization of lysosomal marker (LAMP2) and mitochondrial marker (ATP synthase ), suggesting an inability of the autophagosome to fuse with the lysosome (Sridevi Gurubaran et al., 2020)

For instance, in the Q175 genetic mouse model of HD, human NSCs transplanted into the striatum differentiated into MSN- and interneuron-like cells but did not give rise to observable myelinated tracts under infrared illumination with differential interference contrast (IR-DIC) microscopy