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In this trial, 342 men with sildenafil-failure ED were given either intranasal PT-141 (10 mg dose) or placebo on demand over ~48 weeks.The outcomes demonstrated a clear benefit of bremelanotide: About 33.5% of men on bremelanotide achieved a positive clinical response (improved erections sufficient for intercourse) compared to only 8.5% on placebo

However, in contrast to the healthy controls, the impedance continued to markedly rise above the initial baseline values with an increase in impedance magnitude of |Z| 74.92% 0.69, in-phase impedance (Z re ) of 301.67% 3.55, and out-of-phase impedance (Z im ) of 64.73% 0.62

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