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The STEP 1 trial showed semaglutide produced average weight loss of 14.9% of body weight over 68 weeks, compared with 2.4% with placebo

It is particularly common in individuals with certain risk factors, including those who have undergone gastric or small intestine resections, have inflammatory bowel disease, use metformin or proton pump inhibitors, follow a vegan diet, or are older than 75 years

This distributes the medication more evenly through the tissue

What it does in the MicroInfuser context: dermal hydration (low-MW), volumetric plumping in upper dermis (mid-MW), barrier-protective film in the post-procedure window (high-MW), and CD44 receptor engagement on fibroblasts