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IFN-/ and IFN- are the main cytokines released in response to viral detection, along with other inflammatory cytokines and ISGs

Lupus nephritis (LN) LN is one of the most common and severe organ manifestations in SLE and is a significant contributor to disability and mortality in SLE patients [128]

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Epigenetic mechanismssuch as DNA methylation, histone modifications, noncoding RNAs, and RNA editing-contribute to key neural processes, including learning, memory, and emotional regulation, and are increasingly recognized as central to both depression and drug addiction 16,17,18