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Comparative research examining both compound classes at the TrkB receptor allows investigators to characterise whether observed signalling outcomes depend on receptor engagement mechanism or are specific to one structural class of research tool

In wild-type mice, cagrilintide activates c-Fos-expressing neurons in the dorsal vagal complex (DVC), lateral parabrachial nucleus (LPBN), area postrema, and nucleus tractus solitarius brainstem regions critically involved in satiety signaling and suppression of food intake