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Long-term sleep deprivation could cause hallucinations

DNA methylation was measured using global DNA methylation (5-mC) ELISA

All healthy blood donors provided written informed consent in accordance with the Declaration of Helsinki

Immune cells and metabolites produced by gut bacteria can move through the circulatory system to stimulate immune responses in the lungs, while the lung microbiota can induce microbial changes in the blood and gut ( 2 Microbiota and COPD 2.1 Lung microbiota and COPD Traditionally, lungs are considered sterile spaces, but in fact, they have their own microbial community composed of bacteria, viruses, and fungi ( Proteobacteria, Firmicutes, and Bacteroidetes are the most common genera in COPD patients, while at the genus level, Pseudomonas, Streptococcus, Prevotella, Fusobacteria, and Veillonella are the main genera