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Bottom line on the preclinical class: it shows measurable effects in rodents over days of dosing-plus-training, the best of it is one clean independent study, and it tells you nothing reliable about if or when a human would notice anything

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[6] Sexual Side Effects of Fluoxetine in Men While erectile dysfunction gets the most attention, fluoxetine may also cause: Decreased libido or reduced sexual desire Delayed ejaculation Difficulty achieving orgasm (anorgasmia) Genital anesthesia (reduced sensitivity) Decreased morning erections Lower overall sexual satisfaction [6] These effects relate to altered serotonin-dopamine balance and slowed sexual response

Therefore, to determine whether similar anomalies were present in the mouse models, we performed our studies on young mice between 1 and 2 mo of age (20)