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While direct contact between MenSCs and neurons inhibited neurite elongation, their secreted factorsincluding VEGF, HGF, and brain-derived neurotrophic factorpromoted axonal extension

Bachta et al

Antioxidants (Basel) 2018;7(5):63

These effects were mediated by an increase in phosphorylation of mTOR and/or its downstream substrates, p70-S6 kinase (S6K) and the Eukaryotic translation initiation factor 4E-binding protein-1 (4E-BP1) [21]