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Comprehensive mass spectrometer analysis identified 22 metabolites across four species (rat, dog, monkey, and human) and fifteen metabolites were identified as the new ones, with CYP2D6-mediated biotransformation pathways (including mono-oxygenation, O-demethylation, and oxidation) accounting for the generation of four major metabolites (M1, M10, M13, M17)

Shashi A, Tikka M (2021) Fluoride-induced adrenal insufficiency: adrenocorticotropin endocrine disruption and ultrastructural experimental study

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