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The strongest evidence is at the level of the serotonin transported genes (mainly SLC6A4 ) with candidate genes studies suggesting an increased in methylation in depression (Kang et al., Reference Kang, Kim, Stewart, Kim, Bae, Kim and Yoon2013

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Observational evidence suggests the risk of cardiovascular disease doubles for each increment of 20 mm Hg systolic and 10 mm Hg diastolic above 115/75 mm Hg

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Microorganisms 8 (7), 1018

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10.1016/j.reprotox.2003.10.006 135 van den DriescheS.KilcoyneK

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