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The goal of therapy in dermatomyositis is to improve function in activities of daily living as the result of improvement in muscle strength and alleviate the skin rash

An animal study in a reserpine-induced fibromyalgia rat model found that nano-pregabalin (N-PG) alleviated FM symptoms by enhancing CNS penetration, restoring neurotransmitter balance (Glut, NE, CGRP), increasing antioxidant enzyme activity (e.g., SOD), inhibiting pro-inflammatory transcription factors (e.g., NF-B), and reducing apoptosis by decreasing caspase-3 (Casp-3) activation (36)

Neural crest cells (NCCs) are vital in vertebrate embryonic development, and their behavior is linked to nervous system defects

115,116 There is a clear negative correlation between elevated HCy levels and brain and cognitive function