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Based on above findings, we summarized the metabolic characteristics of different types of DM and proposed the potential mechanism of dysregulation of serum metabolites in the pathogenesis of DM progression, as shown in Table 2 and Figure 5

Conclusion: EVs released from normal LSECs inhibit the activation of HSCs and the inflammatory phenotype of KCs

Emerging evidence indicates extensive crosstalk and hierarchical interactions among these pathways ( Table 2 )

Once injected into the area near the sciatic nerve or the degenerated discs and joints pressing on it, these factors reduce inflammation , encourage tissue regeneration , and promote the restoration of nerve health