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instead, its C-ring interacts with the C terminus of helix 11 and the loop region between helix 11 and helix 12

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Upon heavy metal stress, phytochelatin synthesis is prioritized even in the absence of S

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1