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Abbreviations BMI: Body Mass Index CMA3: Chromomycin A3 FSH: Follicle stimulating hormone GnRH: Gonadotropin releasing hormone LH: Luteinizing hormone MDA: Malondialdehyde NAC: N-Acetylcysteine PRL: Prolactin ROS: Reactive oxygen species T: Testosterone TAC: Total antioxidant capacity References Aitken RJ, De Iuliis GN, Finnie JM, Hedges A, McLachlan RI

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The activation of AMPK has been shown to ameliorate these pathologies

Given that the rs13107325 (p.Ala391Thr) variant has been linked to 22 clinical phenotypes 44,313 , an important question is whether this pleiotropy reflects the diverse roles of Mn as an enzymatic cofactor or a common downstream signaling mechanism