Thorax 67 , 689693 (2012)
It is not yet well-understood how these bacteria can exert these benefits, but documented mechanisms of action include antimicrobial activity against major gastrointestinal 171 and urogenital pathogens 172 , barrier-promoting effects at the gut epithelium 173 and other mucosa 174 , immunomodulatory effects by stimulating host antimicrobial compounds such as - defensins 175 and modulating the secretion of cytokines such as IL-10, IL-6, IL-1b, IL-2, TNF-, and impacting different cell types such as intestinal epithelial cells, dendritic cells, macrophages and regulatory T cells 176,177,178
AGEs are a group of heterogenous compounds formed upon a non-enzymatic reaction between reducing sugars and amino groups of proteins, lipids, or nucleic acids, called Maillard reaction
At Thorne, those principles are embedded in our decades of research, clinical partnerships, and scientific leadership and they define how we formulate, test, and deliver products that make a meaningful difference." Magnesium Glycinate 28-day Study: Measurable Improvements in Sleep, Stress, and Recovery Thorne's Magnesium Glycinate demonstrated meaningful benefits across key wellness areas: 91% reported improvement in sleep 94% reported improved ability to stay calm in stressful situations 84% reported improvements in stress levels, mood, or focus 76% reported improved muscle relaxation or recovery 93% reported a positive overall experience Participants also reported faster sleep onset and improvements in morning refreshment, noting many benefits early in supplementation