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However, whether they can serve as maintenance therapy during remission to regulate the immune system and prevent flares awaits validation from prospective, large-scale studies

doi: 10.1016/j.ijbiomac.2022.06.073 89 LiT.WanM.QingC.GuanX.PiJ.LvH.et al

The induction of MPT triggers release of intermembrane proteins such as apoptosis inducing factor (AIF) and endonuclease G into the cytosol and their translocation to the nucleus, causing nuclear DNA fragmentation and activation of regulated necrosis